diff --git a/config/kernel-bio.m4 b/config/kernel-bio.m4
index 1d715b2de6..df5e9de3be 100644
--- a/config/kernel-bio.m4
+++ b/config/kernel-bio.m4
@@ -191,6 +191,24 @@ AC_DEFUN([ZFS_AC_KERNEL_SRC_BIO_SET_DEV], [
 	], [], [ZFS_META_LICENSE])
 ])
 
+dnl #
+dnl # Linux 5.16 API
+dnl #
+dnl # bio_set_dev is no longer a helper macro and is now an inline function,
+dnl # meaning that the function it calls internally can no longer be overridden
+dnl # by our code
+dnl #
+AC_DEFUN([ZFS_AC_KERNEL_SRC_BIO_SET_DEV_MACRO], [
+	ZFS_LINUX_TEST_SRC([bio_set_dev_macro], [
+		#include <linux/bio.h>
+		#include <linux/fs.h>
+	],[
+		#ifndef bio_set_dev
+		#error Not a macro
+		#endif
+	], [], [ZFS_META_LICENSE])
+])
+
 AC_DEFUN([ZFS_AC_KERNEL_BIO_SET_DEV], [
 	AC_MSG_CHECKING([whether bio_set_dev() is available])
 	ZFS_LINUX_TEST_RESULT([bio_set_dev], [
@@ -205,6 +223,15 @@ AC_DEFUN([ZFS_AC_KERNEL_BIO_SET_DEV], [
 			AC_DEFINE(HAVE_BIO_SET_DEV_GPL_ONLY, 1,
 			    [bio_set_dev() GPL-only])
 		])
+
+		AC_MSG_CHECKING([whether bio_set_dev() is a macro])
+		ZFS_LINUX_TEST_RESULT([bio_set_dev_macro], [
+			AC_MSG_RESULT(yes)
+			AC_DEFINE(HAVE_BIO_SET_DEV_MACRO, 1,
+			    [bio_set_dev() is a macro])
+		],[
+			AC_MSG_RESULT(no)
+		])
 	],[
 		AC_MSG_RESULT(no)
 	])
@@ -434,6 +461,7 @@ AC_DEFUN([ZFS_AC_KERNEL_SRC_BIO], [
 	ZFS_AC_KERNEL_SRC_BLKG_TRYGET
 	ZFS_AC_KERNEL_SRC_BIO_BDEV_DISK
 	ZFS_AC_KERNEL_SRC_BDEV_SUBMIT_BIO_RETURNS_VOID
+	ZFS_AC_KERNEL_SRC_BIO_SET_DEV_MACRO
 ])
 
 AC_DEFUN([ZFS_AC_KERNEL_BIO], [
diff --git a/module/os/linux/zfs/vdev_disk.c b/module/os/linux/zfs/vdev_disk.c
index bcec4c6ba0..0e884f426a 100644
--- a/module/os/linux/zfs/vdev_disk.c
+++ b/module/os/linux/zfs/vdev_disk.c
@@ -493,6 +493,7 @@ vdev_blkg_tryget(struct blkcg_gq *blkg)
 #elif defined(HAVE_BLKG_TRYGET)
 #define	vdev_blkg_tryget(bg)	blkg_tryget(bg)
 #endif
+#ifdef HAVE_BIO_SET_DEV_MACRO
 /*
  * The Linux 5.0 kernel updated the bio_set_dev() macro so it calls the
  * GPL-only bio_associate_blkg() symbol thus inadvertently converting
@@ -514,7 +515,30 @@ vdev_bio_associate_blkg(struct bio *bio)
 	if (q->root_blkg && vdev_blkg_tryget(q->root_blkg))
 		bio->bi_blkg = q->root_blkg;
 }
+
 #define	bio_associate_blkg vdev_bio_associate_blkg
+#else
+static inline void
+vdev_bio_set_dev(struct bio *bio, struct block_device *bdev)
+{
+#if defined(HAVE_BIO_BDEV_DISK)
+	struct request_queue *q = bdev->bd_disk->queue;
+#else
+	struct request_queue *q = bio->bi_disk->queue;
+#endif
+	bio_clear_flag(bio, BIO_REMAPPED);
+	if (bio->bi_bdev != bdev)
+		bio_clear_flag(bio, BIO_THROTTLED);
+	bio->bi_bdev = bdev;
+
+	ASSERT3P(q, !=, NULL);
+	ASSERT3P(bio->bi_blkg, ==, NULL);
+
+	if (q->root_blkg && vdev_blkg_tryget(q->root_blkg))
+		bio->bi_blkg = q->root_blkg;
+}
+#define	bio_set_dev		vdev_bio_set_dev
+#endif
 #endif
 #else
 /*